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World Wide Alzheimer's Disease Neuroimaging Initiative


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World Wide Alzheimer's Disease Neuroimaging Initiative


Australian ADNI


Australian ADNI is the neuroimaging data from the Australian Imaging, Biomarker and Lifestyle Flagship Study of Ageing (AIBL). Funding from the Alzheimer's Association enables the AIBL to make its neuroimaging data available to authorized researchers worldwide through the central ADNI scientific data access portal at the Laboratory of Neuroimaging (LONI) at the University of California at Los Angeles. AIBL brain imaging data have been collected according to ADNI protocols.

AIBL is a long-term longitudinal investigation that aims to advance understanding of the causes of Alzheimer's disease, improve diagnosis, and help develop preventive strategies. The study enrolls volunteers with Alzheimer's disease and mild cognitive impairment (MCI) as well as healthy volunteers.

Launched in November 2006, AIBL has recruited over 1,100 participants aged 60 years and older through two locations in Melbourne, Victoria, and Perth, Western Australia. Study volunteers undergo a comprehensive examination, including neuropsychological testing, clinical assessment, and evaluation of health and lifestyle factors.

Upon enrollment, all volunteers contributed a fasting blood sample. In addition, nearly 300 participants received dual brain imaging studies with both amyloid imaging agent Pittsburgh compound B (PIB) and magnetic resonance imaging (MRI).

Participants will be reassessed at 18-month intervals to determine the value of various biomarkers, cognitive benchmarks and lifestyle factors as indicators of Alzheimer's disease and as predictors of future decline.

The first 18-month follow-up data collection began in 2008. All study participants received repeat neuropsychological and clinical assessments, and those who originally received neuroimaging were asked to undergo additional scans. Imaging data from the first 18-month follow-up were released early in 2011 and early in 2013 on the LONI website. Baseline data are also available in the LONI repository.

In 2010, the Alzheimer's Association awarded part of the funding needed to extend AIBL into a new phase known as AIBL-2. The second phase continues to collect clinical and cognitive data from all study volunteers as well as additional brain images from the previously imaged group.

Additional resources:

  • For more detail about the AIBL, please visit the AIBL website.
  • Researchers interested in applying for authorization to access to AIBL data can find further information on the AIBL website.
  • Researchers seeking access to other ADNI data can visit the ADNI website.

 

Australia